CYP2C19*2 polymorphism and clopidogrel resistance
نویسندگان
چکیده
منابع مشابه
Aspirin and clopidogrel resistance.
Aspirin and clopidogrel provide significant clinical benefit in patients with cardiovascular disease. However, given the complexity of platelet activation, it is not surprising that aspirin or clopidogrel prevent a small proportion of cardiovascular events. Of late, the terms aspirin and clopidogrel "resistance" have entered the physicians' lexicon, and infer a lack of therapeutic response and ...
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Antiplatelet agents are mainly used in the prevention and management of atherothrombotic complications. Dual antiplatelet therapy, combining aspirin and clopidogrel, is the standard care for patients having acute coronary syndromes or undergoing percutaneous coronary intervention according to the current ACC/AHA and ESC guidelines. But in spite of administration of dual antiplatelet therapy, so...
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Clopidogrel, a thienopyridine antiplatelet agent, has been used alone or in association with aspirin to prevent vascular complications in atherothrombotic patients. It is also, in combination with aspirin, the key treatment to prevent stent thrombosis in patients who have undergone percutaneous coronary intervention. It is estimated that 40 million patients worldwide receive clopidogrel. Recent...
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D ual antiplatelet therapy combi ning aspirin and clopidogrel is the standard care for patients who have acute coronary syndromes (ACS) or are undergoing percutaneous coronary in tervention (PCI), according to the current ACC/AHA and ESC guidelines. How ever, despite the administration of dual antiplatelet therapy, some patients do de velop recurrent cardiovascular ischemic events, with ste...
متن کاملSimultaneous Two-Vessel Subacute Stent Thrombosis Caused by Clopidogrel Resistance from CYP2C19 Polymorphism
Clopidogrel resistance from CYP2C19 polymorphism has been associated with stent thrombosis in patients undergoing percutaneous coronary intervention with drug-eluting stents. We present a case of a 76-year-old male who received drug-eluting stents to the right coronary artery and left anterior descending artery for non-ST elevation myocardial infarction and was discharged on dual antiplatelet t...
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ژورنال
عنوان ژورنال: Archivos de cardiolog?a de M?xico (English ed Internet)
سال: 2021
ISSN: ['2604-7063']
DOI: https://doi.org/10.24875/acme.m20000160